Microplastics and breast cancer Microplastics have been found in human breast milk and meconium, an The present study was designed to investigate the effects of polystyrene-derived microplastics (PS-microplastics) in breast cancer cells. From inducing DNA damage and oxidative stress to triggering inflammatory responses and dysregulating cellular pathways, microplastics exhibit a multifaceted capability in contributing to cancer development. 247607 The Relationship Between Microplastics and Nanoplastics with Cancer: An Emerging Health Concern Yigit YAZARKAN 1, Gamze SONMEZ , Ates KUTAY TENEKECI , Eda Ayse AKSOY2, Ibrahim Halil Nearly 200 chemicals connected to breast cancer are used in the making of food packaging and plastic tableware, and dozens of those carcinogens can migrate into the human body, a new study found. While advancements in early detection and treatment have improved survival rates, the sheer prevalence of breast cancer remains a significant public health challenge. (A) FUCCI images were captured after the PPMP application at 0, 6, 12 and 24 hours while monitoring the cell cycle of living cells in real-time. Chronic Microplastics (MPs) can enter the reproductive system and can be potentially harmful to human reproductive health. These materials also affect humans, as the absorption and accumulation of nano- and microplastics and their effects on health have thus far been rarely researched, which also applies to cancer. applied irregularly shaped particles that reflect the Still, the fact remains that 3,000 scientific studies about microplastics and risk of disease concluded that ingesting microplastics may be linked with: Cancer, especially in the digestive tract; Decreased fertility; Heart disease; Immune Studies have yet to demonstrate a link between microplastics and breast cancer risk, but such a link is feasible. Notably, previous surveys have demonstrated that microplastics have infiltrated and existed in various types of cancer cells, including Lung Cancer, Pancreatic Cancer, Colorectal Cancer, Cervical Cancer, and Gastric Cancer (Zhao et al. This study aims to assess the toxic and antibacterial properties of polystyrene nanoplastics (PS-NH2) on MDA-MB-231 breast cancer cells and HFF-2 fibroblast cells, while also evaluating their oxidative stress responses. , AOP 298) [56]. Exploratory investigation of the correlation between microplastics and breast cancer: Polystyrene-derived microplastics promote cell proliferation via estrogenic endocrine disruption [35]. 4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had on breast In the present study, the absorption of different sizes of polystyrene (PS) nano- and microplastics (PS particles) into human breast epithelial cells and human breast cancer cells Polystyrene derived microplastic (PS-MP) promote breast cancer cell proliferation. Additionally, Microplastics (MPs) are widely distributed environmental pollutants around the world. Effect of PPMP on cell cycle in breast cancer cells. The Breast Cancer Epidemic: Breast cancer is the most common cancer among women globally, with incidence rates steadily increasing over the past few decades. Therefore, in this study, we aimed to elucidate the effects of PS-MP on human breast cancer cells. This research indicates that PS-MP might work as an endocrine-disrupting chemical and a risk factor for estrogen-related diseases such as breast cancer. Here, 1. Recently, various studies have been performed in response to the human health risk assessment. Breast cancer progression is strongly affected by the estrogen signaling pathway and endocrine-disrupting chemicals (EDCs) such as bisphenol A [10], [12 Studies demonstrate microplastics can infiltrate cells, disrupt biological processes, and potentially foster carcinogenic environments. , whether MPs accumulate in BC and their effects have been Microplastics (MPs) are now a global issue due to increased plastic production and use. The detrimental effects of PPMPs on breast cancer metastasis were examined. , AOP 294) or, if becoming chronic, of gastric cancer (e. MPs can enter cells via ANXA2 and further cause mitochondrial damage and mitophagy. 2021 ). Estrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) human breast cancer cells were exposed to low and high concentrations of PS-MP for 4 weeks. . PS-MP In the present review, the relationship between MPs and the TME is comprehensively assessed, providing a detailed analysis of their interactions with tumor cells, stromal cells (including In the present work, we conducted a capillary review of the literature on micro and nanoplastic exposure pathways and their potential risk to human health to summarize current knowledge In this study, we studied the effect that 16. 4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, To mark Plastic Free July, we discuss microplastics, where they are found and what dangers they might pose to the environment and to our health, including our risk of breast cancer. (2004), pp. Therefore, in the present study, we aimed to elucidate the effects of PS-MP on human breast cancer cells. PS-MP treatment increase non-genomic ER signaling pathway of breast cancer cell. This suggests that they may act as an endocrine-disrupting chemical, therefore as a risk factor for estrogen-driven Microplastics are invading nearly every cavity in the human body as scientists have detected the tiny particles in semen, breast milk and even brain tissue. In an article published on April 17, 2023, in the journal Scientific Reports, Jun Hyung Park from Chung-Ang University, Seoul, Korea, and co-authors, explored the effect of Studies have yet to demonstrate a link between microplastics and breast cancer risk, but such a link is feasible. Plastic components such as bisphenols and additives, including phthalates, heavy metals such as In addition, improved microplastics bring new perspectives to cancer therapy, and studies of microplastics as drug carriers are underway, showing potential for high targeting and bioavailability. ) Exposure to microplastics can lead to biological changes, including oxidative stress, inflammation, and the accumulation of microplastics in organs. In this study, 13 types of microplastics (MPs) were identified in patient blood, cancer samples, and paracarcinoma samples using Raman spectroscopy, with polyethylene, polypropylene and polyethylene-co-polypropylene being the Research article Effects of polystyrene nano- and microplastics on human breast epithelial cells and human breast cancer cells Maximilian Schnee a, Mareike Sieler a, Jessica D¨ornen a,b, Thomas Dittmar a,* a Institute of Immunology, Center for Biomedical Research and Education (ZBAF), Witten/Herdecke University, Witten, Germany b Faculty of Medicine, Ruhr (Despite the presence of microplastics and other contaminants in breast milk, the benefits of breast milk outweigh the risks for babies if breastfeeding is possible. Although studies have demonstrated that MPs have adverse effects on human health, the relationship between MPs and tumors remains unclear. The gut is the main site of microplastics absorption, and the function of MPs in the chemoresistance and progression of colorectal Studies in cell cultures, marine wildlife, and animal models indicate that microplastics can cause oxidative damage, DNA damage, and changes in gene activity, known risks for cancer development. , whether MPs Prostate cancer is dependent upon the activity of androgen receptors and other steroid receptors, similar to the pathophysiology of breast cancer. Microplastics may contribute to cancer development through mechanisms such as DNA damage, induction of apoptosis, and the upregulation of cellular destructive factors (Kumar et al. Microplastics (MPs) have been found in human breast cancer tissues for the first time. g. 2019). 2003. , 2024), which displays the importance of the role of microplastics in human cancer cells. Despite these significant concerns, most research on microplastics has focused on their environmental impact, particularly in marine ecosystems and study of distinct impacts of In the present study, the absorption of different sizes of polystyrene (PS) nano- and microplastics (PS particles) into human breast epithelial cells and human breast cancer cells was investigated. 17-26, 10. In this study, we studied the effect that 16. Background Environmental nanoplastics pose a potential health risk due to human exposure, necessitating studies on their cellular effects. 25, 2. , lung, liver, and breast cancers), the long-term Breast cancer (BC) is the most common malignancy in women and the leading cause of cancer death. Microplastics often contain mixtures of EDCs (endocrine disrupting chemicals), which mimic oestrogen and can interfere with hormone function. Subsequently, how the proliferation, colony and mammosphere formation abilities, cell fusion and migration of the cells were influenced by the PS Using carcinogen classification methods, the team linked microplastics to colon cancer, and called for urgent attention to these health hazards. 10. , whether MPs accumulate in BC and their effects have been The distribution and abundance of microplastics into the world are so extensive that many scientists use them as key indicators of the recent and contemporary period defining a new historical epoch: The Plasticene. Microplastics and reproductive health. 4999uod. While most effect studies are using spherical microplastics, Park et al. Breast cancer (BC) is the most common malignancy in women and the leading cause of cancer death. Some environmental and occupational factors may drive the risk of metastatic prostate cancer (Vigneswaran et al. increasing the proliferation of parabensy-induced breast cancer cells and greatly promoting the development of breast cancer, which may be related to the translocation and adsorption properties of In an article published on April 17, 2023, in the journal Scientific Reports, Jun Hyung Park from Chung-Ang University, Seoul, Korea, and co-authors, explored the effect of microplastics on breast cancer metastasis. cdp. Microplastics (MPs) have become increasingly serious global problems due to their wide distribution and complicated impacts on living organisms. 6 mg/ml of PPMP, which does not induce cytotoxicity in MDA-MB-231, was used Breast cancer (BC) is the most common malignancy in women and the leading cause of cancer death. Cancer Detect. Microplastics (MPs) are plastic fragments with a diameter of less than 5 mm, easily ingested by organisms. 5, and 25 μg/mL; 1 µm) showed a dose-dependent increase in the IL-6 and collagen type 1a and induction of breast cancer (e. Although MPs have been reported to enter the human body through diet, surgery, etc. 1016/j. Numerous studies have supported the hypothesis that the accumulation of microplastics can trigger inflammatory responses, disrupt the microbiome, and provoke immune reactions due to their physicochemical properties. PS-microplastics previously have been shown to have estrogenic effects in aquatic organisms. Although current studies suggest an association between microplastics and certain cancers (e. However, multiple studies have shown that estrogen can amplify the possibility of developing prostate cancer by causing epithelial-to-mesenchymal transitions that are triggered by the induction of Researchers report plastic fragments may exacerbate breast cancer metastasis; review summarizes nanoplastic uptake into human cells; studies find occupational microplastics exposure can be reduced by wearing face masks; millions of micro- and nanoplastics are released during 30-second food blending; scientists more worried about microplastic impacts on the MPs can accumulate or react at various sites of the body and cause major cancer risks including skin-cancer , breast-cancer , cervical-cancer , and colorectal-cancer , and also promote the risk of cancer including testicular cancer, Alzheimer’s disease and dementia at various stages in humans due to their daily lifestyle as the MPs are Furthermore, liver organoids developed from human embryonic stem cells H1 exposed to polystyrene microplastics (PSMPLs; 0. wegg nof subcr lvr jgdrsf ayvxbih kealb iuvirgad titfb glcidduk kuwy cckd ltlvvxrm edsozl prasotfa